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Longevity & Healthspan Optimization

Modern medicine checks the box.
We change the numbers.

Know your numbers. Know what to do about them. Have a team behind you until they move.

Get My Protocol 60 seconds · Free · See your personalized plan
Standard Care "Cholesterol is borderline" "Watch your sugar" "Lose some weight" "Everything looks fine" "Get more exercise" "You're just stressed" "That's just aging" "See you next year" "Cholesterol is borderline"
Protocol Cut your ApoB in half Measure and manage your metabolic health Build the muscle that extends your life Find what's quietly going wrong Train your cardio fitness back ten years Measure your cortisol and fix the source Optimize your hormones with evidence Give you a plan before you leave the first call Cut your ApoB in half

Your doctor has a 2,500 patient panel.
We keep ours deliberately small.

That's the difference between "your labs look fine" and a team that tracks your numbers, adjusts your plan, and doesn't stop until they move.

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Currently accepting new members.

Your Team

A deliberately small practice.
Your team knows your future.

Dr. Gil Blander, PhD

Dr. Gil Blander, PhD

Chief Scientific Officer

20+ years in biomarker research. Founded InsideTracker.

Dr. Ajay Haryani, MD

Dr. Ajay Haryani, MD

Medical Director

Board-certified. Internal medicine.

Dr. Rue Laka, MD

Dr. Rue Laka, MD

Healthspan Director

Preventive medicine. Leads protocol clinical design.

Susanna Wiborg, RN

Susanna Wiborg, RN

VP Operations

Coordinates your care across every protocol and provider.

Paige McGlone, RN

Paige McGlone, RN

Care Team Lead

Your primary contact. Tracks your progress weekly.

Mary Stratos, PA-C, IFMCP

Mary Stratos, PA-C

Physician Assistant

Integrative and functional medicine certified. Manages your protocols.

Caitlyn Castiglione, MS, RDN

Caitlyn Castiglione, RDN

Registered Dietitian

Nutrition strategy tailored to your biomarkers and goals.

Case Studies

What changes when your doctor
actually looks.

Four members. Different risks. Measurable outcomes tracked with labs, DEXA, and VO2 max testing over 6 to 14 months.

The Challenge

His primary care physician said his cardiac risk was "low." Standard lipid panel looked unremarkable. But his family history told a different story: father stented at 68, maternal grandfather had a stroke at 52, maternal grandmother developed heart failure and dementia.

What Protocol Did

  • Ordered ApoB and LDL particle count — tests his PCP had never run. ApoB came back at 122 mg/dL (should be <90), LDL-P at 2,014 nmol/L (should be <1,130)
  • CT coronary artery calcium scan revealed a score of 105 — silent atherosclerosis already present at age 46
  • Started rosuvastatin 20mg daily with LDL target of 60-65 mg/dL
  • DEXA scan revealed osteopenia — prescribed impact training and weighted carries
  • Identified B12 deficiency causing essential tremor — started monthly IM injections

Results

LDL169 mg/dL70 mg/dL-59%
Total Chol.220 mg/dL127 mg/dL-42%
Cardiac Risk4.22.4-43%
ASCVD 10yr2.01%1.00%-50%
B12269 pg/mL791 pg/mLTremor resolved

Why This Matters

Three tests that standard primary care rarely orders — ApoB, LDL particle count, and a CAC scan — revealed that atherosclerosis was already building silently in his coronary arteries at age 46. His standard lipid panel looked "fine." Without these tests, he might not have discovered this until a cardiac event in his 50s or 60s.

The Challenge

Strong family history of Alzheimer's and cardiovascular disease. Low grip strength flagged by physiology assessment. Below-average lean mass for her frame. Prior weight loss goal met, but strength progress limited.

What Protocol Did

  • Identified elevated LDL (131 mg/dL) and family-driven cognitive risk as top priorities
  • Started low-dose rosuvastatin for LDL reduction
  • Prescribed creatine monohydrate for muscle building and cognitive neuroprotection
  • Designed non-weight-bearing-on-hands strength protocol around prior yoga injury
  • Structured protein-focused nutrition plan
  • Optimized HRT: transitioned to separate transdermal estradiol patch + oral progesterone

Results

Lean Mass73.4 lbs84.6 lbs+15.3%
Left Grip44.1 lbs52.9 lbs+20.0%
VAT18.3 in³15.7 in³-14.2%
LDL131 mg/dL43 mg/dL-67.2%

Why This Matters

At 58, most women lose approximately 1% of lean mass per year. Member R gained lean mass at 10x the expected rate of loss while keeping weight stable — replacing fat tissue with muscle tissue. Her 20% grip strength improvement directly reduces fall risk and correlates with longevity outcomes.

The Challenge

Elevated cholesterol, hypertension requiring medication, and a family history dense with cardiovascular disease — both parents, a brother, and grandmother all had high cholesterol. Systemic inflammation marker (hs-CRP) elevated at 2.5 mg/L, placing him in the moderate-to-high cardiovascular risk category.

What Protocol Did

  • Comprehensive risk profiling: ApoB, advanced lipid panel, inflammatory markers
  • Started low-dose rosuvastatin 10mg after ApoB came back at 107 mg/dL (optimal is <90)
  • Targeted systemic inflammation through dietary anti-inflammatory strategies
  • Caught HbA1c at 5.5% — trending toward prediabetes. Recommended CGM trial
  • DEXA confirmed excellent bone density — one of the strongest results in the cohort

Results

ApoB107 mg/dL71 mg/dL-34%
hs-CRP2.5 mg/L0.3 mg/L-88%
Triglycerides146 mg/dL67 mg/dL-54%
Bio Age53 chrono43.1 bio-9.9 years

Why This Matters

Four independent cardiovascular risk markers all improved dramatically within six months. The hs-CRP drop from 2.5 to 0.3 cut systemic inflammation by 88%, moving him from moderate risk to the lowest risk category. His biological age of 43.1 — nearly a decade younger than his calendar age — reflects the cumulative effect.

The Challenge

Advanced genetic testing revealed two significant risk factors: one APOE4 variant (increased Alzheimer's risk) and elevated Lipoprotein(a), a genetic cardiovascular risk factor. Below-average hip bone density with family history of osteoporosis and early menopause.

What Protocol Did

  • Identified APOE4 carrier status and elevated Lp(a) — neither detected in standard primary care
  • Alzheimer's mitigation through exercise, sleep optimization, and cognitive engagement
  • Calcium score test ordered to assess plaque burden given genetic risk factors
  • Heavy compound lifts prescribed specifically for hip bone density
  • VO2 max target set at 39-40 with HIIT prescription (rowing machine)

Results

Fat Mass45.7 lbs37.6 lbs-17.7%
Weight146.1 lbs136.5 lbs-6.6%
Fat:Lean Loss5:1 ratiovs 3:1 typical

Why This Matters

Of the 9.6 lbs lost, 8.1 lbs was fat and only 1.6 lbs was lean mass — a 5:1 fat-to-lean loss ratio vs. the 3:1 typical of most diets. More importantly, Protocol's genetic testing identified two lifetime risk factors (APOE4 and Lp(a)) she can now manage proactively for decades.

See all member journeys →

Anonymized data from a self-selected cohort, not a controlled trial. These results are from individual members and should not be expected by all participants. Outcomes depend on individual health conditions, adherence, and clinical factors. Results achieved through physician-prescribed interventions including medication management. No compensation was provided for sharing results. See aggregate outcomes and full methodology →

"For the first time, I have a care plan that's actually aligned with my goals. We're not just aiming for 'good enough.' We're aiming for strong, active, and thriving."

Protocol member · Individual results vary

Why Protocol

You've probably tried one of these.

The annual physical

Designed to catch disease. Not to prevent it.

Standard panels haven't kept up. ApoB, Lp(a), VO2 max? Rarely ordered. "Normal" means not flagged yet, not optimal for you. What your annual misses.

The 100-biomarker panel

Great data. Missing the second half.

100+ results back. No clinical team to turn them into a plan. You end up coordinating your own care. Function Health vs Protocol.

The concierge doctor

Nicer office. Same playbook.

You're paying thousands a year for availability, not a different approach. Executive physical vs Foundation Assessment.

"I had multiple PCPs tell me I was 'fine' and miss a torn hip labrum. The dichotomy between Protocol and traditional healthcare has been amazing to experience." — Protocol member, 2 years

Investment

Transparent pricing.
No surprises.

Foundation Assessment

$1,500

Your starting point.

  • + Expansive bloodwork panel
  • + DEXA body composition scan
  • + Strength & mobility testing
  • + Foundation Consultation
  • + Personalized Longevity Plan

Included with annual membership

Learn More

One-time · May qualify for HSA/FSA reimbursement

Common Questions

Frequently Asked Questions

Due Diligence

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